Clinical Associations of Thyroid Hormone Levels with the Risk of Atherosclerosis in Euthyroid Type 2 Diabetic Patients in Central China
Table 1
Anthropometric characteristics of the study population with and without previously diagnosed CVD.
Total
Without atherosclerosis
With atherosclerosis
value
N
910
537 (59.0%)
373 (41.0%)
Age (years)
51.9 (13.1)
46.3 (11.4)
59.9 (11.0)
<0.001
BMI (kg/m2)
25.3 (3.8)
25.5 (4.0)
24.9 (3.4)
0.044
Gender (%)
0.126
F
523 (57.5%)
320 (35.2%)
203 (22.3%)
M
387 (42.5%)
217 (23.8%)
170 (18.7%)
Smoking status (%)
0.005
Nonsmoker
529 (58.1%)
289 (31.8%)
240 (26.4%)
Ex-smoker
110 (12.1%)
73 (8.0%)
37 (4.1%)
Smoker
271 (29.8%)
175 (19.2%)
96 (10.5%)
Years of T2D
5 [2, 10]
3 [0.6, 6]
10 [7, 15]
<0.001
HbA1c (%)
8.4 [7.2, 9.9]
8.4 [7.1, 9.9]
8.4 [7.4, 9.9]
0.218
FPG
8.4 [6.8, 10.7]
8.3 [6.8, 10.5]
8.7 [7.0, 10.9]
0.343
Thyroid hormones
FT3 (pmol/L)
4.41 [4.11, 4.76]
4.5 [4.19, 4.87]
4.26 [3.95, 4.6]
<0.001
FT4 (pmol/L)
16.14 [14.64, 17.75]
16.38 [14.76, 18.23]
15.68 [14.42, 17.46]
0.001
TSH (μIU/mL)
2.11 [1.36, 3.10]
1.99 [1.30, 3.04]
2.21 [1.43, 3.17]
0.083
FT3/FT4
0.27 [0.25, 0.31]
0.28 [0.25, 0.31]
0.27 [0.25, 0.3]
0.328
Blood pressure
SBP (mmHg)
135 [122, 149]
132 [120, 145]
138 [126, 153]
<0.001
DBP (mmHg)
85 [80, 90]
86 [80, 90.75]
83 [79, 90]
0.013
Lipid profiles
TC (mmol/L)
4.88 [4.2, 5.62]
4.83 [4.20, 5.58]
4.92 [4.22, 5.67]
0.582
TG (mmol/L)
1.62 [1.10, 2.63]
1.71 [1.11, 2.81]
1.55 [1.1, 2.27]
0.029
HDL-C (mmol/L)
1.11 [0.95, 1.27]
1.1 [0.94, 1.26]
1.12 [0.96, 1.30]
0.252
LDL-C (mmol/L)
2.92 [2.36, 3.5]
2.95 [2.35, 3.48]
2.92 [2.36, 3.53]
0.868
T2D treatments
Diet
107 (11.8%)
96 (10.5%)
11 (1.2%)
<0.001
Oral drugs
529 (58.1%)
357 (39.2%)
172 (18.9%)
<0.001
Insulin injection
94 (10.3%)
53 (5.8%)
41 (4.5%)
0.662
Oral drugs and insulin
180 (19.8%)
31 (3.4%)
149 (16.4%)
<0.001
History of other diseases
CVD
396 (43.5%)
108 (11.9%)
288 (31.6%)
<0.001
Hypertension
532 (58.5%)
247 (27.1%)
285 (31.3%)
<0.001
Hyperlipidemia
392 (43.1%)
156 (17.1%)
236 (25.9%)
<0.001
Family history of T2D
469 (51.5%)
299 (32.9%)
170 (18.7%)
0.006
Medications
Hypertension
408 (44.8%)
156 (17.1%)
252 (27.7%)
<0.001
Hyperlipidemia
242 (26.6%)
65 (7.1%)
177 (19.5%)
<0.001
Data are expressed as mean (SD), median (25% quantile, 75% quantile), or count (percentage) depending on the variable type. The value was calculated by independent two-sample t-tests, Mann–Whitney U test, or chi-square test accordingly.When , when , and when . BMI: body mass index; FPG: fasting plasma glucose; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglycerides; LDL-C: low-density lipoprotein cholesterol; and HDL-C: high-density lipoprotein cholesterol.
