Would Cortisol Measurements Be a Better Gauge of Hydrocortisone Replacement Therapy? Congenital Adrenal Hyperplasia as an Exemplar

Figure 5

Relationship between plasma androstenedione concentration and 24-hour mean plasma cortisol concentration in 34 children with salt-wasting congenital adrenal hyperplasia showing step effect at 150 nmol/l. The black bar shows the normal range of 24-hour mean plasma cortisol concentrations (drawn at 20-minute intervals over 24 hours) in 80 normal adult individuals (aged between 60 and 70 years; see [2]). Reproduced from Congenital Adrenal Hyperplasia: A Comprehensive Guide, Hindmarsh P and Geertsma K Elsevier, New York (2017).