Would Cortisol Measurements Be a Better Gauge of Hydrocortisone Replacement Therapy? Congenital Adrenal Hyperplasia as an Exemplar

Figure 7

Temporal relationship between cortisol (blue line and diamonds) and 17 hydroxyprogesterone (purple line and triangles) in a 12-year old pubertal female with salt-wasting congenital adrenal hyperplasia following the administration of hydrocortisone at 08.00 h (5 mg) and 14.30 h (2.5 mg) (daily dose 11 mg/m2/day) showing the lag between the peak cortisol concentrations at 08 : 40 h and 15 : 20 h and effect on plasma 17 hydroxyprogesterone concentrations. Blood samples are drawn at 20-minute intervals. Reproduced from Congenital Adrenal Hyperplasia: A Comprehensive Guide, Hindmarsh P and Geertsma K Elsevier, New York (2017).