Would Cortisol Measurements Be a Better Gauge of Hydrocortisone Replacement Therapy? Congenital Adrenal Hyperplasia as an Exemplar

Figure 8

Full plasma 17 hydroxyprogesterone concentration profile (purple line and triangles) from the patient described in Figure 4 to illustrate the effect of sampling interval on the data obtained. Samples as (a) three time point spot samples (green triangles) before dosing with hydrocortisone and (b) how a single (orange triangle) or three (green triangles) time point samples do not reflect what is taking place over the 24-hour period. Blood samples are taken hourly to construct the profile. Reproduced from Congenital Adrenal Hyperplasia: A Comprehensive Guide, Hindmarsh P and Geertsma K Elsevier, New York (2017).

(a)

(b)