Research Article
The Association between eGFR and the Aldosterone-to-Renin Ratio and Its Effect on Screening for Primary Aldosteronism
Table 2
Test characteristics of ARR to screen for PA according to stratified GFR.
| | eGFR | Optimal cut-off | Sensitivity (95% CI) | Specificity (95% CI) | Positive LR (95% CI) | Negative LR (95% CI) |
| | ALL | 18 | 100.0 (95.4–100.0) | 71.38 (67.6–75.0) | 3.5 (3.1–4.0) | — | | 40 | 92.4 (84.2–97.2) | 90.3 (87.7–92.6) | 9.6 (7.4–12.3) | 0.1 (0.0-0.1) | | 52 | 82.3 (72.1–90.0) | 94.7 (92.6–97.3) | 15.5 (10.9–22.0) | 0.2 (0.1–0.3) | | <90 | 18 | 100.0 (87.2–100.0) | 95.3 (92.0–97.6) | 21.3 (12.3–37.1) | — | | 40 | 85.2 (66.3–95.8) | 100.0 (98.6–100.0) | — | 0.2 (0.1–0.4) | | 52 | 85.2 (66.3–95.8) | 100.0 (98.6–100.0) | — | 0.2 (0.1–0.4) | | ≥90 | 18 | 100.0 (93.2–100.0) | 90.7 (87.2–93.6) | 10.8 (7.8–15.0) | — | | 40 | 100.0 (93.2–100.0) | 90.7 (87.2–93.6) | 10.8 (7.8–15.0) | — | | 52 | 98.1 (89.7–100.0) | 95.4 (92.6–97.3) | 21.2 (13.1–34.2) | 0.0 (0.0-0.1) |
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ARR, aldosterone-to-renin ratio; eGFR, estimated glomerular filtration rate; PA, primary aldosteronism; LR, likelihood ratios; CI, confidence interval.
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