Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome

Table 2

Results of the treatment with ALA plus MI in the patients divided into subgroups according to the presence of IR and of DRs.

		BMI (kg/m^2)	FSH (mIU/mL)	LH (mIU/mL)	Estradiol (pmol/L)	Total testosterone (ng/mL)	Androstenedione (ng/mL)	Fasting insulin (pmol/L)	HOMA-IR	AUC-insulin (pmol/L × 120 min)
IR	Baseline	31.08 ± 5.81	5.49 ± 1.70	11.08 ± 4.95	253.32 ± 216.13	2.32 ± 0.42	11.49 ± 4.33	108.40 ± 25.21	3.31 ± 0.91	76749.93 ± 44293.96
	6 months	30.25 ± 6.31	4.90 ± 2.79	9.07 ± 6.50	394.89 ± 314.82	2.22 ± 0.55	10.86 ± 4.22	74.72 ± 20.21	2.13 ± 0.66	61385.76 ± 19343.06
No IR	Baseline	25.74 ± 4.34	7.38 ± 3.30	13.08 ± 7.83	278.47 ± 293.23	2.39 ± 0.73	11.77 ± 4.82	51.74 ± 17.22	1.51 ± 0.57	47095.35 ± 24335.69
	6 months	25.32 ± 3.89	5.30 ± 2.35	10.69 ± 6.97	418.28 ± 353.26	2.36 ± 0.73	13.02 ± 4.40	57.01 ± 25.07	1.67 ± 0.73	45636.11 ± 21788.68
With DRs	Baseline	26.47 ± 4.54	7.47 ± 4.64	10.44 ± 4.84	341.99 ± 389.93	2.29 ± 0.76	11.42 ± 1.86	63.89 ± 29.58	1.85 ± 0.89	64158.06 ± 49596.88
	6 months	25.61 ± 4.14	5.61 ± 2.33	11.22 ± 7.40	440.85 ± 375.32	2.29 ± 0.73	13.55 ± 4.85	61.53 ± 20.63	1.80 ± 0.64	49730.97 ± 19476.60
Without DRs	Baseline	27.27 ± 5.50	6.52 ± 1.64	13.70 ± 8.03	232.73 ± 177.07	2.43 ± 0.62	11.87 ± 3.42	67.43 ± 33.06	2.05 ± 1.10	50767.08 ± 21370.14
	6 months	26.91 ± 5.37	4.95 ± 2.52	9.74 ± 6.56	396.36 ± 324.47	2.36 ± 0.66	12.01 ± 4.12	61.60 ± 27.15	1.78 ± 0.78^a	49970.42 ± 23582.92

All data are reported as the mean ± SD. 17 women had IR, and 49 did not. Women with IR showed a reduction of BMI, fasting insulin, and HOMA-IR and an increase in estradiol, while women without IR showed an increase in estradiol and a reduction of FSH. 26 women had DRs, and 45 did not. Women with DRs only showed a significant reduction of BMI, while women without DRs showed a significant reduction of FSH and LH and an increase of estradiol, with a tendency to a reduction of HOMA-IR. vs. baseline; vs. baseline; ^a. ALA: α-lipoic acid; AUC: area under the curve; BMI: body mass index; DRs: diabetic relatives; FSH: follicle-stimulating hormone; HOMA-IR: homeostasis model assessment of insulin resistance; IR: insulin resistance; LH: luteinizing hormone; MI: myo-inositol; PCOS: polycystic ovary syndrome; SD: standard deviation.