gp91^phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism

Table 1

Clinical characteristics of four groups in the study.

	Healthy controls	Controls with high LDL	SH with normal LDL	SH with high LDL
	n = 13	n = 12	n = 11	n = 15
Gender (F/M）	10/3	9/3	9/2	11/3	0.978	-
Age (years)	50.38 ± 3.52	50.33 ± 4.12	54.09 ± 6.88	51.60 ± 7.60	0.202	0.423
BMI (kg/m^2)	22.9 ± 2.21	23.15 ± 2.48	24.48 ± 2.62	24.44 ± 2.31	0.343	0.172
TC (mmol/L)	4.56 ± 0.37	5.41 ± 0.39	5.54 ± 0.53	6.31 ± 1.00	<0.001	<0.001
LDL-C (mmol/L)	2.27 ± 0.53	3.65 ± 0.30	2.86 ± 0.28	4.02 ± 0.61	N/A	N/A
HDL-C (mmol/L)	1.35 ± 0.13	1.19 ± 0.13	1.18 ± 0.16	1.45 ± 0.34	0.021	0.782
TG (mmol/L)	1.05 ± 0.34	1.16 ± 0.36	1.15 ± 0.34	1.40 ± 0.34	0.144	0.020
FBG (mmol/L)	5.08 ± 0.41	4.97 ± 0.65	5.50 ± 0.73	6.58 ± 2.18	0.008	0.169
FT3 (pmol/L)	5.20 ± 0.62	5.47 ± 0.36	4.93 ± 0.71	4.73 ± 0.28	0.002	0.028
FT4 (pmol/L)	16.41 ± 1.58	17.76 ± 1.65	15.36 ± 1.85	15.59 ± 2.04	0.013	0.397
TSH (mIU/L)	2.22 ± 0.92	2.19 ± 0.85	6.62 ± 1.98	7.17 ± 2.58	N/A	N/A

, nonparametric one-way Kruskal–Wallis for all the four groups; , healthy controls vs. SH with high LDL. BMI : body mass index; TC : total cholesterol; LDL-C : low-density lipoprotein cholesterol; HDL-C : high-density lipoprotein cholesterol; TG : triglyceride; FBG : fasting blood glucose; FT3 : free triiodothyronine; FT4 : free thyroxine; TSH: thyroid stimulating hormone.