Review Article
Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease
Table 1
Role of exosomal contents in TC development.
| Exosomal origin | Author | Contents | Function | Level | Reference |
| Serum | Luo et al. | SRC | Regulate tumor metastasis via activating MAPK/ERK and focal adhesion kinase (FAK) pathways | Overexpress | [46] |
| Hypoxic PTC cells | Wu et al. | miRNA-21-5p | Via miRNA-21-5p/TGFBI and miRNA-21-5p/COL4A1 pathway to promote angiogenesis of HUVECs | Overexpress | [47] |
| PTC serum | Ye et al. | miRNA-432-5p | Accelerating the lymph node metastasis | Overexpress | [48] |
| TC-derived cell lines | Hardy | SNAIL | Repressing CDH1 transcription and promoting the development of PTC | Overexpress | [49] |
| CSCs | Hardin | Linc-ROR | Trigger EMT and induce the local tumor microenvironment and the distant metastatic niche | Overexpress | [36] |
| TPC-1 cell lines and 8505 cells | Boufraqech | miR-145 | Via inhibiting the PI3K/Akt pathway to suppress the growth and transfer of TC | Downexpress | [52] |
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