Association of rs944289, rs965513, and rs1443434 in TITF1/TITF2 with Risks of Papillary Thyroid Carcinoma and with Nodular Goiter in Northern Chinese Han Populations

Table 2

Genotype and allele distributions of the three SNPs in PTCs, NGs, and NCs.

Genotype/allele	PTC	NG	NC	χ^2
rs944289
C/C	255 (29.8)	176 (31.7)	315 (35.5)	16.473	0.002	0.003
C/T	416 (48.7)	244 (43.9)	422 (47.6)
T/T	184 (21.5)	136 (24.5)	150 (16.9)
C	926 (54.2)	596 (53.6)	1052 (59.3)	12.821	0.002
T	784 (45.8)	516 (46.4)	722 (40.7)
rs965513
G/G	647 (76.8)	449 (82.2)	704 (81.4)	16.768	0.002	0.007
A/G	181 (21.5)	85 (15.6)	157 (18.2)
A/A	14 (1.7)	12 (2.2)	4 (0.5)
G	1475 (87.6)	983 (90.0)	1565 (90.5)	8.181	0.017
A	209 (12.4)	109 (10.0)	165 (9.5)
rs1443434
T/T	590 (70.7)	409 (78.5)	651 (76.1)	18.014	0.001	0.003
T/G	217 (26.0)	107 (20.5)	190 (22.2)
G/G	28 (3.4)	5 (1.0)	14 (1.6)
T	1397 (83.7)	925 (88.8)	1492 (87.3)	16.533	<0.001
G	273 (16.3)	117 (11.2)	218 (12.7)

, value of linear-by-linear association test. PTC, papillary thyroid carcinoma; NG, nodular goiter; NC, normal control. Significant values in bold.