Association of rs944289, rs965513, and rs1443434 in TITF1/TITF2 with Risks of Papillary Thyroid Carcinoma and with Nodular Goiter in Northern Chinese Han Populations

Table 3

Association between rs944289 polymorphism and PTC/NG.

Genotype/allele	PTC vs. NC			NG vs. NC
	OR (95% CI)		AIC	OR (95% CI)		AIC
Codominant
C/C	1.00	0.010	2411.1	1.00	0.003	1835.4
C/T	1.22 (0.98–1.51)			1.06 (0.83–1.36)
T/T	1.52 (1.15–1.99)			1.66 (1.22–2.26)
Dominant
C/C	1.00	0.011	2411.9	1.00	0.092	1842.5
C/T + T/T	1.30 (1.06–1.58)			1.22 (0.97–1.54)
Recessive
C/C + C/T	1.00	0.014	2412.4	1.00	0.001	1833.6
T/T	1.35 (1.06–1.71)			1.60 (1.22–2.10)
Overdominant
C/C + T/T	1.00	0.650	2418.1	1.00	0.240	1844.0
C/T	1.04 (0.87–1.26)			0.88 (0.70–1.09)
Allele
C	1.00	0.002	—	1.00	0.002	—
T	1.23 (1.08–1.41)			1.28 (1.10–1.50)

Adjusted by age. PTC, papillary thyroid carcinoma; NG, nodular goiter; NC, normal control. Bonferroni correction was performed, and was defined as statistical significance. Significant values after Bonferroni correction in bold.