Association of rs944289, rs965513, and rs1443434 in TITF1/TITF2 with Risks of Papillary Thyroid Carcinoma and with Nodular Goiter in Northern Chinese Han Populations

Table 6

Cumulative risk alleles of the three SNPs and association with PTC.

No.	PTC	NG	NC	χ^2			OR (95% CI)
0	146 (18.0)	108 (21.5)	178 (21.7)	29.881	0.001	<0.001	1.25 (1.13–1.37)	<0.001
1	298 (36.8)	194 (38.6)	338 (41.2)
2	231 (28.5)	147 (29.3)	222 (27.1)
3	111 (13.7)	44 (8.8)	76 (9.3)
4	17 (2.1)	8 (1.6)	6 (0.7)
5	7 (0.9)	1 (0.2)	0 (0.0)
Total	810 (100.0)	502 (100.0)	820 (100.0)

OR (95% CI) and value were calculated by binary logistic regression for PTC vs. NC. , value of linear-by-linear association test. PTC, papillary thyroid carcinoma; NG, nodular goiter; NC, normal control. Significant values in bold.