Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice

Figure 6

Transverse section of testes exposed to baicalein (BC) without or with testosterone (T) injection. Scale bar = 50 μm. (a), (e) Testis of control mice showing the presence of normal tubular structure with spermatogenic cells at different stages of development. (b) Testis of F1 mice exposed to 30 mg·BC/kg body weight (BW) showing the wide lumen with a less number of sperm and spermatogenic cells. (c) Testis of F1 mice exposed to 60 mg·BC/kg BW showing wide intratubular space with a less number of sperm in the lumen. (d) Testis of F1 mice exposed to 90 mg·BC/kg BW showing large lumen devoid of sperm. (f), (g), and (h) Testis of F1 mice injected with 4.19 mg·T/kg BW to 30, 60, and 90 mg·BC/kg BW, respectively, showing seminiferous tubules filled with spermatozoa.