Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice
Table 1
Administration of testosterone (T) on reproductive performance of adult male mice exposed to baicalein (BC) prenatally.
Parameters
Group
Control/BC-exposed groups
4.16 mg· T/kg BW (BC + T) (#)
Mating index (%)
Control
100 (6/6)
100 (6/6)
30 mg
100 (6/6)
100 (6/6)
60 mg
100 (6/6)
100 (6/6)
90 mg
100 (6/6)
100 (6/6)
Fertility index (%)
Control
100%
100%
30 mg
83.3%
100%
60 mg
66.6%
75%
90 mg
50%
75%
No. of corpora lutea/mice
Control
13.5 ± 0.22
13.25 ± 0.25
30 mg
12.66 ± 0.21 (−6.22),
12.00 ± 0.0 (−7.54),
60 mg
11.83 ± 0.40 (−12.37),
13.00 ± 0.0 (−1.88),
90 mg
12 ± 0.44 (−11.11),
12.50 ± 0.28 (−5.66),
,F = 5.082
,F = 2.280
Implantation (%)
Control
100
100
30 mg
95.94
100
60 mg
91.26
95.80
90 mg
86.24
98.07
No. of implantations/mice
Control
11.16 ± 0.31
10.75 ± 0.25
30 mg
10.5 ± 0.22 (−5.97),
10.25 ± 0.29 (−2.32),
60 mg
8.16 ± 0.31 (−26.86),
10.25 ± 0.25 (−4.65),
90 mg
5.3 ± 0.55 (−52.23),
10.25 ± 0.47 (−5.65),
,F = 92.36
,F = 0.5077
No. of live fetus/mice
Control
10.83 ± 0.166
10.00 ± 0.41
30 mg
10.17 ± 0.16 (−6.15),
9.50 ± 0.29 (−5),
60 mg
7.67 ± 0.42 (−29.23),
9.750 ± 0.25 (−2.5),
90 mg
4.83 ± 0.48 (−55.38),
10.00 ± 0.41 (0),
,F = 89.69
,F = 0.3708
Resorption (%)
Control
0
0
30 mg
5.34
0
60 mg
8.73
1.92
90 mg
13.75
1.92
No. of resorptions/mice
Control
0
0
30 mg
0.67 ± 0.42,
0,
60 mg
1.00 ± 0.36,
0.5 ± 0.28,
90 mg
1.83 ± 0.47,
0.25 ± 0.25,
,F = 4.088
,F = 1.941
Resorption index (%)
Control
0
0
30 mg
6.67
0
60 mg
12.63
2.5
90 mg
32.69
2.27
Postimplantation loss (%)
Control
2.98
0
30 mg
3.17
2.38
60 mg
6.12
2.44
90 mg
9.36
4.87
Values are mean ± SEM of six animals. # denotes n = 4. Values in the parentheses are percent changes from that of control (“−” indicates decrease). Significance was checked from controls to BC exposed and prenatal BC exposed with T groups. Significance was considered at , where BW = body weight.
