Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice
Table 2
Administration of testosterone (T) on body weight (gm) and tissue indices (W/W%) of adult male mice exposed to baicalein (BC) prenatally.
Tissue
Group
Control/BC-exposed groups
4.16 mg T/kg·BW (BC + T) (#)
Body weight
Control
38.02 ± 0.91
38.87 ± 1.45
30 mg
35.71 ± 0.84 (6.07),
35.22 ± 0.41(−9.39),
60 mg
35.35 ± 0.74 (−7.02),
35.45 ± 0.71 (−8.78),
90 mg
35.36 ± 0.56 (−7.00),
36.84 ± 0.96 (−5.22),
,F = 7.111
,F = 2.706
Brain
Control
0.46 ± 0.01
0.45 ± 0.0008
30 mg
0.40 ± 0.02 (−13.48),
0.43 ± 0.01 (−4.03),
60 mg
0.42 ± 0.02 (−9.03),
0.43 ± 0.01 (−4.14),
90 mg
0.35 ± 0.03 (−22.94),
0.44 ± 0.02 (−2.26),
,F = 2.368
,F = 0.5778
Liver
Control
2.59 ± 0.11
2.52 ± 0.068
30 mg
1.95 ± 0.16 (−24.91),
2.25 ± 0.03 (−10.75),
60 mg
1.69 ± 0.15 (−34.78),
2.29 ± 0.11 (−8.91),
90 mg
1.58 ± 0.13 (−0.15),
2.27 ± 0.10 (−9.91),
,F = 10.81
,F = 3.900
Kidney
Control
0.84 ± 0.08
0.83 ± 0.118
30 mg
0.74 ± 0.07 (−11.77),
0.81 ± 0.01 (−2.27),
60 mg
0.49 ± 0.07 (−41.87),
0.80 ± 0.02 (−3.29),
90 mg
0.42 ± 0.03 (−50.13),
0.76 ± 0.01 (−8.68),
,F = 13.26
,F = 0.2431
Spleen
Control
0.22 ± 0.012
0.22 ± 0.015
30 mg
0.17 ± 0.01 (−25.49),
0.21 ± 0.001 (−5.22),
60 mg
0.19 ± 0.05 (−13.65),
0.19 ± 0.02 (−16.21),
90 mg
0.14 ± 0.02 (−34.33),
0.21 ± 0.02 (−8.59),
,F = 1.084
,F = 1.879
Testis
Control
0.275 ± 0.011
0.26 ± 0.013
30 mg
0.21 ± 0.02 (23.29),
0.23 ± 0.01 (−11.42),
60 mg
0.19 ± 0.01 (−29.46),
0.21 ± 0.01 (−22.09),
90 mg
0.15 ± 0.01 (−46.64),
0.23 ± 0.01 (−14.13),
,F = 16.99
,F = 3.000
Epididymis
Control
0.90 ± 0.058
0.99 ± 0.070
30 mg
0.84 ± 0.03 (−11.14),
0.90 ± 0.01 (−8.38),
60 mg
0.74 ± 0.05 (−27.20),
0.89 ± 0.03 (−9.61),
90 mg
0.67 ± 0.06 (−28.58),
0.92 ± 0.03 (−7.09),
,F = 8.08
,F = 1.111
Seminal vesicle
Control
0.26 ± 0.0028
0.26 ± 0.001
30 mg
0.22 ± 0.003 (−15.10),
0.26 ± 0.001, (−1.04),
60 mg
0.18 ± 0.001 (−29.45),
0.25 ± 0.003 (−4.65),
90 mg
0.11 ± 0.004 (−95.90),
0.26 ± 0.002 (−2.27),
,F = 52.99
,F = 3.848
Prostate
Control
0.07 ± 0.003
0.08 ± 0.004
30 mg
0.06 ± 0.004 (−13.13),
0.06 ± 0.001, (−7.06),
60 mg
0.05 ± 0.004 (−27.07),
0.06 ± 0.001 (−13.19),
90 mg
0.04 ± 0.01 (−40),
0.05 ± 0.001 (−5.27),
,F = 20.03
,F = 5.931
Values are mean ± SEM of six animals. # denotes n = 4. Values in the parentheses are percent changes from that of control (“−” indicates decrease). Significance was checked from control males to F1 BC exposed and BC exposed administered with T groups. Significance was considered at , where BW = body weight.
