International Journal of Endocrinology / 2020 / Article / Tab 1

Review Article

The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 1

Systematic review of randomized controlled trials evaluating the effects of metformin in overweight women with polycystic ovary syndrome.

AuthorSample size (T/C)Mean age (T/C)BMI (T/C)NationInterventionControlMetformin interventionOutcome measured
Frequency (per day)Dose (mg)Duration (week)

Curi et al. [22]20/2024.6 ± 1.3/26.3 ± 1.431.1 ± 1.5/31.8 ± 1.6BrazilMetforminUsual care controls + placebo treatment2850 mg24①②③④⑤⑥⑬⑭

Esfahanian et al. [23]17/1321.9 ± 9.3/20 ± 4.631.1 ± 3.3/34.1 ± 5.4IranMetforminUsual care controls + hypocaloric diet1000 mg/day gradually to 2000 mg/day12①②⑦⑧⑨⑩⑪⑫⑬

Otta et al. [24]15/1525.47 ± 4.82/24.7 ± 3.4632.4 + 6.7/35.6 + 4.98BrazilMetforminUsual care controls + placebo treatment2750 mg16①②④⑤⑦⑧⑨⑩⑪⑫⑬⑭

Gambineri et al. [25]10/1026·1 ± 4·5/27·1 ± 3·637·0 ± 5·9/37·6 ± 4·1ItalyMetforminUsual care controls + placebo treatment2850 mg24①⑥⑦⑧⑨⑩⑪⑫⑬⑭

Gambineri et al. [26]20/202 8 ± 8/26 ± 535 ± 4/37 ± 5ItalyMetforminUsual care controls + placebo treatment2850 mg48①②⑥⑦⑧⑪⑫

Hoeger et al. [27]9/1129.5 ± 6.4/27.1 ± 4.537.1 ± 4.9/37.1 ± 4.6United StatesMetforminUsual care controls + placebo treatment2850 mg48①②⑥

Bonakdaran et al. [28]17/1625.9 ± 4.5/25.2 ± 7.928.2 ± 5.03/25.3 ± 5.1IranMetforminUsual care controls + placebo treatment21000 mg12①④⑪⑫⑬

Karimzadeh Javedani [29]90/7527.33 ± 2.34/27.48 ± 2.6927.17 ± 1.73/27.92 ± 1.05IranMetforminUsual care controls + placebo treatment21500 mg24①②⑦⑧

Lord et al. [30]16/1627.76 ± 4.89/30.63 ± 4.8433.74 ± 6.74/36.37 ± 7.46United KingdomMetforminUsual care controls + placebo treatment3500 mg12①②④⑥⑦⑧⑨⑩⑪⑫⑬

Tang et al. [31]69/7429.7 ± 3.7/29.8 ± 3.837.6 ± 5.0/38.9 ± 9.5United KingdomMetforminUsual care controls + placebo treatment2850 mg24①②⑥⑨⑩⑪⑫⑬

Tiwari et al. [32]33/3324.33 ± 3.89/24.46 ± 4.7625.23 ± 4.64/26.32 ± 3.68IndiaMetforminUsual care controls + fixed exercise2850 mg24①②⑬

Yarali et al. [33]32/3229.7 ± 5.6/28.4 ± 5.128.6 ± 4.0/29.6 ± 4.8TurkeyMetformin + rFSHUsual care controls + placebo treatment2850 mg6①②③⑤⑫⑬⑭

Months were converted to weeks by using 1 month = 4 weeks; years were converted by using 1 year = 52 weeks. BMI: body mass index; WC: waist circumference; FSH: follicle-stimulating hormone; HOMA-IR: homeostasis model assessment of insulin resistance; LH: luteinizing hormone; SHBG: sex hormone-binding globulin; HDL: high-density lipoprotein; LDL: low-density lipoprotein; TC: total cholesterol; TG: triglycerides; and FBG: fasting blood glucose. ① BMI; ②WC; ③ FSH; ④ HOMA-IR; ⑤ LH; ⑥SHBG; ⑦ HDL; ⑧ LDL; ⑨ TC; ⑩ TG; ⑪ FBG; ⑫ fasting insulin;⑬ testosterone; and ⑭ androstenedione.

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