Effect of Preoperative Vitamin D Deficiency on Hypocalcemia in Patients with Acute Hypoparathyroidism after Thyroidectomy
Table 3
Comparison of clinical and biochemical parameters during hospitalization between VDD and non-VDD groups.
Parameters
VDD (n = 21)
Non-VDD (n = 22)
value
Preoperative laboratory values
25(OH)D level (ng/mL)
15.44 ± 3.3
26.89 ± 4.2
<0.01
PTH (pg/mL)
52.86 ± 20.8
47.45 ± 16.1
0.34
Albumin-adjusted calcium (mg/dL)
9.14 ± 0.4
9.26 ± 0.4
0.32
Phosphate (mg/dL)
3.45 ± 0.6
3.45 ± 0.4
0.99
eGFR (ml/min/1.73 m2)
105.07 ± 22.4
95.59 ± 20.3
0.26
Postoperative laboratory values
PTH (pg/mL)
Postoperative day 0
11.40 ± 3.59
9.66 ± 3.29
0.11
Postoperative day 1
11.58 ± 3.26
9.54 ± 3.37
0.05
Postoperative day 2
12.78 ± 7.82
9.67 ± 3.63
0.13
Albumin-adjusted calcium (mg/dL)
Postoperative day 0
8.12 ± 0.45
8.42 ± 0.23
0.01
Postoperative day 1
8.09 ± 0.43
8.34 ± 0.54
0.09
Postoperative day 2
7.83 ± 0.61
8.52 ± 0.60
<0.01
Lowest albumin-adjusted calcium (mg/dL)
7.71 ± 0.50
8.16 ± 0.35
<0.01
Phosphate (mg/dL)
Postoperative day 0
3.82 ± 0.78
3.93 ± 0.64
0.64
Postoperative day 1
4.42 ± 0.86
4.47 ± 0.95
0.85
Postoperative day 2
4.27 ± 0.91
4.26 ± 1.25
0.99
Magnesium POD-0 (mg/dL)
1.65 ± 0.18
1.74 ± 0.12
0.05
Percentage of PTH decline (%)
75.79 ± 13.4
77.96 ± 12.4
0.58
Symptomatic hypocalcemia
9 (42.9%)
2 (9.1%)
0.01
Required intravenous calcium treatment
7 (33.3%)
2 (9.1%)
0.07
Maximal calcium supplement per day (mg)
2400 (1800, 3600)
1500 (1200, 2400)
0.02
Maximal alfacalcidol supplement per day (mcg)
1 (1, 2)
1 (0.5, 1)
0.08
Length of hospital stay (days)
5 (4, 8)
4 (4, 6)
0.06
Patients requiring readmission
0 (0.0%)
0 (0.0%)
—
Data are presented as mean ± SD, number and percentage, or median and IQR. A value < 0.05 indicates statistical significance. VDD: vitamin D deficiency; 25(OH)D: 25-hydroxyvitamin D; PTH: parathyroid hormone; eGFR: estimated glomerular filtration rate; POD: postoperative day; SD: standard deviation; IQR: interquartile range.
