The Dose-Response Relationship between Gamma-Glutamyl Transferase and Risk of Diabetes Mellitus Using Publicly Available Data: A Longitudinal Study in Japan

Table 3

Threshold effect analysis of GGT on incident diabetes mellitus in the NAGALA study, 2004–2015.

Outcome:	HR (95% CI)	value
One-line linear regression model	1.00 (1.00, 1.01)	0.0922
Two-piecewise linear regression model
GGT <24	1.04 (1.02, 1.07)	0.0017
GGT ≥24	1.00 (0.99, 1.01)	0.9733
Log-likelihood ratio test	0.003

Notes: adjusted for age, gender, smoking status, alcohol intake, body mass index, systolic blood pressure, fatty liver, triglycerides, alanine aminotransferase, aspartate aminotransferase, and fasting plasma glucose. Abbreviations: GGT, gamma-glutamyl transferase; HR, hazard ratio; CI, confidence interval.