Research Article
Quality of Life in Patients with Acromegaly before and after Transsphenoidal Surgical Resection
Table 2
Difference of quality of life change in remission, discordant, and active patients.
| | | Remission | Discordant | Active | | | (N = 71) | (N = 36) | (N = 44) |
| | Baseline characteristics | | Age (years) | 45.3 (12.5) | 41.5 (11.2) | 43.6 (12.9) | 0.318 | | Gender (male) | 34 (47.9%) | 17 (47.2%) | 24 (54.5%) | 0.743 | | BMI (kg/m2) | 25.4 (2.9) | 25.5 (3.3) | 26.7 (4.2) | 0.122 | | Preoperative medication | 8 (11.3%) | 7 (19.4%) | 14 (31.8%) | 0.025 | | Diabetes mellitus | 17 (23.9%) | 11 (30.6%) | 10 (22.7%) | 0.687 | | Hypertension | 22 (31.0%) | 4 (11.1%) | 14 (31.8%) | 0.056 | | Nadir GH (ng/mL) | 15.7 (13.6) | 20.3 (14.9) | 27.8 (24.6) | 0.004 | | IGF index | 2.5 (1.0) | 2.3 (0.8) | 2.7 (0.9) | 0.178 | | T3 (nmol/L) | 2.1 (1.3) | 2.1 (1.7) | 2.2 (1.7) | 0.949 | | T4 (nmol/L) | 94.8 (23.4) | 94.0 (24.2) | 97.0 (25.1) | 0.857 | | Free T3 (pmol/L) | 5.3 (1.6) | 5.2 (1.9) | 8.0 (17.5) | 0.307 | | Free T4 (pmol/L) | 18.4 (12.6) | 18.7 (17.5) | 18.1 (8.8) | 0.979 | | Testosterone (nmol/L) | 7.8 (3.8) | 14.5 (25.3) | 6.1 (7.2) | 0.111 | | SF36 | 65.6% [63.9%, 72.1%] | 65.3% [62.1%, 66.6%] | 65.4% [63.2%, 67.7%] | 0.521 | | AcroQoL | 58.2% [51.8%, 71.8%] | 67.7% [51.8%, 71.8%] | 64.1% [51.8%, 71.8%] | 0.982 | | 6-month follow-up | | SF36 | 76.1% [61.4%, 81.9%] | 78.2% [63.7%, 88.9%] | 75.3% [70.1%, 82.3%] | 0.431 | | AcroQoL | 75.0% [59.3%, 87.3%] | 76.4% [57.3%, 89.3%] | 82.7% [74.1%, 88.6%] | 0.335 | | Change of QoL after surgery | | SF36 | 11.1% [−1.5%, 16.1%] | 18.7% [−0.7%, 35.7%] | 11.0% [2.5%, 20.7%] | 0.384 | | AcroQoL | 7.0% [2.2%, 31.0%] | 14.5% [5.8%, 24.4%] | 15.4% [2.4%, 39.6%] | 0.647 |
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