Research Article
Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity
Table 2
Clinical and biochemical characteristics according to each HP phenotype.
| | | Hp1-1 | Hp1-2 | Hp2-2 | value |
| | Subjects | 26 | 97 | 68 | ns | | Sex (M/F) | 11/15 | 50/47 | 30/38 | ns | | Age (years) | 10.7 ± 2.7 | 11.4 ± 2.8 | 11.8 ± 2.8 | ns | | P/PP | 16/10 | 66/31 | 49/19 | ns | | Height (cm) | 151.0 ± 16.2 | 150.0 ± 14.8 | 150.9 ± 14.0 | ns | | Weight (kg) | 70.3 ± 24.6 | 66.7 ± 16.6 | 69.9 ± 19.4 | ns | | BMI (kg/m2) | 29.9 ± 5.4 | 28.9 ± 4.3 | 30.1 ± 4.6 | ns | | BMI z-score (kg/m2) | 2.3 ± 0.5 | 2.3 ± 0.4 | 2.2 ± 0.5 | ns | | Waist circumference (cm) | 87.4 ± 16.6 | 90.5 ± 12.9 | 94.1 ± 13.0 | ns | | SBP (mmHg) | 128.1 ± 15.2 | 125.3 ± 18.3 | 128.2 ± 20.1 | ns | | DBP (mmHg) | 82.2 ± 10.7 | 82.2 ± 10.4 | 80.6 ± 12.5 | ns | | Total cholesterol (mg/dL) | 141.5 ± 27.6 | 143.1 ± 25.4 | 143.4 ± 25.3 | ns | | LDL-c (mg/dL) | 82.7 ± 22.9 | 84.4 ± 23.8 | 85.9 ± 21.6 | ns | | HDL-c (mg/dL) | 43.1 ± 7.1 | 42.2 ± 10.1 | 40.7 ± 7.8 | ns | | Triglycerides (mg/dL) | 78.3 ± 36.5 | 77.2 ± 43.0 | 82.7 ± 40.7 | ns | | GlcT0' (mg/dL) | 89.4 ± 1.5 | 88.4 ± 0.7 | 89.2 ± 0.1 | ns | | GlcT30' (mg/dL) | 133.4 ± 4.2 | 134.2 ± 2.3 | 136.9 ± 2.6 | ns | | GlcT60' (mg/dL) | 115.4 ± 4.9 | 115.8 ± 2.7 | 127.4 ± 3.0 | | | GlcT90' (mg/dL) | 110.3 ± 4.4 | 110.4 ± 2.4 | 120.8 ± 2.7 | | | GlcT120' (mg/dL) | 109.3 ± 3.7 | 108.7 ± 2.1 | 116.5 ± 2.3 | | | InsT0' (mUI/L) | 20.2 ± 2.5 | 17.8 ± 1.3 | 20.7 ± 1.5 | ns | | InsT30' (mUI/L) | 94.0 ± 17.1 | 130.5 ± 8.8 | 151.1 ± 10.1 | | | InsT60' (mUI/L) | 79.1 ± 20.8 | 99.1 ± 11.7 | 128.9 ± 13.0 | | | InsT90' (mUI/L) | 76.1 ± 55.4 | 76.7 ± 10.5 | 128.7 ± 11.8 | | | InsT120' (mUI/L) | 64.4 ± 19.5 | 75.4 ± 12.0 | 128.7 ± 13.5 | | | HOMA-IR | 4.5 ± 3.0 | 4.3 ± 2.9 | 4.6 ± 3.3 | ns | | ISI | 2.80 ± 1.22 | 2.53 ± 0.80 | 2.91 ± 2.60 | ns | | QUICKI | 0.321 ± 0.021 | 0.312 ± 0.030 | 0.311 ± 0.052 | ns |
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All data are expressed as mean ± SD (standard deviation). Significance is relative to the trend. BMI: body mass index; DBP: diastolic blood pressure; F: female; GlcT0': fasting glucose; HDL-c: high-density lipoprotein-cholesterol; HOMA-IR: homeostatic model assessment of insulin resistance; IFG: impaired fasting glucose; IGT: impaired glucose tolerance; InsT0': fasting insulin; ISI: insulin sensitivity index; Hp: haptoglobin; LDL-c: low-density lipoprotein-cholesterol; M: male; ns: not significant; P: pubertal; PP: prepubertal; QUICKI: Quantitative Insulin-Sensitivity Check Index; SBP: systolic blood pressure.
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