Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy

Table 1

Patients’ characteristics: age 65–80 months and mean age 6 years.

Family history	Nonremarkable, N = 3 (33.3%); Hypothyroidism, N = 2 (22.2%); Developmental delay, N = 2 (22.2%); Epilepsy, N = 1 (11.1%); Attention deficit hyperactivity disorder, N = 1 (11.1%)
Gestation and delivery period (abnormalities)	Preterm delivery, N = 9 (100%); Cesarean section, N = 9 (100%); Low birth weight, N = 9 (100%)
Psychomotor development	Retarded, N = 9 (100%); Mild intellectual disability, N = 4 (44.4%); Moderate intellectual disability, N = 3 (33.3%); Severe intellectual disability, N = 2 (22.2%)
Neurological examination	Spastic diplegia, N = 3 (33.3%); Right hemiparesis, N = 2 (22.2%); Left hemiparesis, N = 2 (22.2%); Spastic tetraplegia, N = 2 (22.2%)
Electroencephalography	Generalized paroxysmal changes, N = 9 (100%)
Seizures’ morphology	Myoclonic seizures (MS), N = 9 (100%); Tonic-clonic seizures (GTCS), N = 9 (100%)
Antiepileptic treatment	Valproic acid (VPA), N = 9 (100%); Levetiracetam (LEV), N = 9 (100%)
Brain MRI	Periventricular leukomalacia (PVL), N = 9 (100%)