Impact of the Italian Society of Anatomic Pathology and Diagnostic Cytology Classification of Thyroid Nodules in the Treatment of Indeterminate Follicular Lesions: Five-Year Results at a Single Center

Table 2

Surgical treatment, demographic, and pathologic data.

	TIR 3A (n = 29)	TIR 3B (n = 90)	value
TIRADS score
3, 4a, 4b (low-intermediate risk)	26	76
Benign/malignant	22/4	57/19
4c, 5 (high risk)	3^♦	14^♦
Benign/malignant	2/1	5/9
Nodule major diameter, mm (range)	23.4 ± 14 (4–60)	29 ± 18 (4–80)
Type of surgery
HT	10	37
TT	19	53
Reasons for TT
Bilateral goiter	12	28
Autoimmune thyroid disease	4	5
Nodule growing in size	3	7
BRAF/RAS mutation	9	12
Prior head & neck irradiation	0	0
Family history of thyroid cancer	0	1
Completion thyroidectomy	0 (0%)	4 (10.8%)	0.56
Malignancy	5 (17.2%)	28 (31.1%)	0.16
pT1a	4	17¶
pT1b	1	3
pT2	0	5
pT3	0	3
Multifocality/TTs for cancer	1/4 (25%)	5/26 (19.2%)	Ns
Unilobar	0	0
Bilobar	1	5
Extrathyroid invasion	0	2 (7.1%)	Ns
Vascular invasion	0	1 (3.6%)	Ns
Aggressive variants	0	0	—
Lymph node metastases/lymph node dissections	1/1	0/2	—
Morphology
Taller than wide	4	17
Oval/round shape	25	73
Margins
Irregular	3	5
Regular	26	85
Microcalcifications
Yes	5	12
No	24	78
Echogenicity
Hypoechogen	6	44
Nonhypoechogen	23	46
Echostructure
Solid	21	77
Mixed	8	13

Note. Data are presented as mean ± SD where applicable. TT, total thyroidectomy; HT, hemithyroidectomy; ns, nonsignificant. ^♦0 cases of TIRADS 5 reported. in bilateral goiter, size of the dominant nodule. ¶ one case of benignity of TIR3B lesion and coexistent occult PTMC in the controlateral lobe.