Impact of the Italian Society of Anatomic Pathology and Diagnostic Cytology Classification of Thyroid Nodules in the Treatment of Indeterminate Follicular Lesions: Five-Year Results at a Single Center
Table 2
Surgical treatment, demographic, and pathologic data.
TIR 3A (n=29)
TIR 3B (n = 90)
value
TIRADS score
3, 4a, 4b (low-intermediate risk)
26
76
Benign/malignant
22/4
57/19
4c, 5 (high risk)
3♦
14♦
Benign/malignant
2/1
5/9
Nodule major diameter, mm (range)
23.4 ± 14 (4–60)
29 ± 18 (4–80)
Type of surgery
HT
10
37
TT
19
53
Reasons for TT
Bilateral goiter
12
28
Autoimmune thyroid disease
4
5
Nodule growing in size
3
7
BRAF/RAS mutation
9
12
Prior head & neck irradiation
0
0
Family history of thyroid cancer
0
1
Completion thyroidectomy
0 (0%)
4 (10.8%)
0.56
Malignancy
5 (17.2%)
28 (31.1%)
0.16
pT1a
4
17¶
pT1b
1
3
pT2
0
5
pT3
0
3
Multifocality/TTs for cancer
1/4 (25%)
5/26 (19.2%)
Ns
Unilobar
0
0
Bilobar
1
5
Extrathyroid invasion
0
2 (7.1%)
Ns
Vascular invasion
0
1 (3.6%)
Ns
Aggressive variants
0
0
—
Lymph node metastases/lymph node dissections
1/1
0/2
—
Morphology
Taller than wide
4
17
Oval/round shape
25
73
Margins
Irregular
3
5
Regular
26
85
Microcalcifications
Yes
5
12
No
24
78
Echogenicity
Hypoechogen
6
44
Nonhypoechogen
23
46
Echostructure
Solid
21
77
Mixed
8
13
Note. Data are presented as mean ± SD where applicable. TT, total thyroidectomy; HT, hemithyroidectomy; ns, nonsignificant. ♦0 cases of TIRADS 5 reported. in bilateral goiter, size of the dominant nodule. ¶ one case of benignity of TIR3B lesion and coexistent occult PTMC in the controlateral lobe.