Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients

Table 3

Correlation between lumbar bone mineral density levels and clinical variables among hemodialysis patients.

Variables	Lumbar bone mineral density (g/cm^2)
	Simple linear regression		Multivariable linear regression
	R	value	Beta	Adjusted R^2 change	value
Female	−0.490	<0.001	−0.256	0.048	0.001
Age (years)	−0.321	0.001	−0.181	0.044	0.012
Log-HD duration (months)	−0.089	0.382	—	—	—
Height (cm)	0.531	<0.001	—	—	—
Pre-HD body weight (kg)	0.570	<0.001	0.219	0.325	0.008
Waist circumference (cm)	0.429	<0.001	—	—	—
Body mass index (kg/m^2)	0.418	<0.001	—	—	—
Systolic blood pressure (mmHg)	0.105	0.305	—	—	—
Diastolic blood pressure (mmHg)	0.011	0.913	—	—	—
Total cholesterol (mg/dL)	−0.076	0.456	—	—	—
Log-triglyceride (mg/dL)	0.220	0.029	—	—	—
Log-glucose (mg/dL)	0.084	0.409	—	—	—
Albumin (mg/dL)	0.239	0.018	0.148	0.017	0.044
Globulin (mg/dL)	−0.029	0.780	—	—	—
Blood urea nitrogen (mg/dL)	0.037	0.715	—	—	—
Creatinine (mg/dL)	0.220	0.029	—	—	—
Total calcium (mg/dL)	0.005	0.957	—	—	—
Phosphorus (mg/dL)	0.123	0.229	—	—	—
Log-iPTH (pg/mL)	−0.127	0.214	—	—	—
Log-leptin (ng/mL)	0.568	<0.001	0.483	0.184	<0.001
Urea reduction rate	−0.382	<0.001	—	—	—
Kt/V (gotch)	-0.380	<0.001	—	—	—

Data of triglyceride, glucose, iPTH, and leptin levels showed skewed distribution and therefore were log-transformed before the analysis. Analysis of data was performed using the simple linear regression analysis or multivariable stepwise linear regression analysis (adapted factors were gender, age, height, pre-HD body weight, waist circumference, body mass index, log-triglyceride, albumin, creatinine, log-leptin, urea reduction rate, and Kt/V). HD, hemodialysis; iPTH, intact parathyroid hormone; Kt/V, fractional clearance index for urea. was considered statistically significant.