Research Article
Clinical Characteristics and Spermatogenesis in Patients with Congenital Hypogonadotropic Hypogonadism Caused by FGFR1 Mutations
Table 2
Comparison of clinical characteristics between the FGFR1 gene group and the mutation-negative group at baseline.
| Groups | FGFR1 mutation (n = 14) | Mutation-negative (n = 25) | |
| Kallmann/nCHH (n/n) | 8/6 | 20/5 | 0.156 | Gonadotropin/GnRH pulsatile (n/n) | 10/4 | 12/13 | 0.193 | Number of testosterone users before sperm promoting therapy (n, %) | 11, 78.57% | 12, 480.00% | 0.093 | Previous testosterone treatment course (years) | 1 (1–2) (n = 11) | 1 (0.5–4) (n = 12) | 0.441 | Cryptorchidism or history of cryptorchidism (n, %) | 7, 50.0% (Unilateral/Bilateral = 3/4) | 3, 12.0% (Unilateral/Bilateral = 1/2) | 0.019 | Age of start for spermatogenic treatment (years) | 20.00 (18.75–24.75) | 24.12 ± 5.75 | 0.297 | Baseline testicular size (mL) | 1.6 (0.5–2.0) | 2.0 (1.75–4) | 0.033 | Baseline LH (IU/L) | 0.20 (0.10–0.70) | 0.35 (0.20–0.72) | 0.318 | Baseline FSH (IU/L) | 1.01 ± 0.85 | 0.60 (0.22–1.58) | 0.714 | Baseline testosterone (ng/dL) | 24.1 (18.58–37.25) | 32.70 (20.65–46.5) | 0.198 | LH 60 min after triptorelin stimulating test (IU/L) | 2.3 (1.16–5.68) | 1.75 (0.77–5.78) | 0.529 | Nonreproductive phenotype | Obesity (n = 2) | Obesity (n = 3); diabetes (n = 1); solitary kidney (n = 1); strabismus (n = 1); unilateral ptosis (n = 1); multiple facial nevi (n = 1); | |
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