Clinical Characteristics and Spermatogenesis in Patients with Congenital Hypogonadotropic Hypogonadism Caused by FGFR1 Mutations

Table 4

Semen parameters after sperm-inducing treatment.

Groups		FGFR1 mutation (n = 14)	Mutation-negative (n = 24)
Cumulative rate of sperm concentration >5 million	1 years	14.39%	30.00%	0.312
	2 years	61.04%	61.11%	0.489
Cumulative rate of sperm concentration >10 million	1 years	14.29%	25.63%	0.435
	2 years	38.64%	57.58%	0.243
Cumulative rate of sperm concentration >15 million	1 years	0.00%	21.25%	0.075
	2 years	34.38%	48.32%	0.252
Cumulative rate of sperm concentration >20 million	1 years	0.00%	21.43%	0.076
	2 years	25.93%	35.18%	0.455
Ejaculate volume (mL)		2.20 (1.40–2.26) (n = 11)	3.06 ± 1.42 (n = 19)	0.175
Sperm concentration (million/mL)		7.19 (1.00–9.91) (n = 11)	18.80 (4.58–53.62) (n = 19)	0.038
Fast progressive sperm (A) (%)		18.00 ± 19.92 (n = 11)	16.77 ± 13.00 (n = 19)	0.839
Sperm progressive motility (A + B) (%)		33.83 ± 26.31 (n = 11)	34.88 ± 22.71 (n = 19)	0.909
Sperm total mobility (A + B + C) (%)		37.26 ± 29.21 (n = 11)	40.38 ± 24.91 (n = 19)	0.759

Sperm concentration, sperm volume, fast progressive sperm, sperm progressive motility, and sperm total mobility were obtained from the last visit.