Research Article
Clinical Characteristics and Spermatogenesis in Patients with Congenital Hypogonadotropic Hypogonadism Caused by FGFR1 Mutations
Table 4
Semen parameters after sperm-inducing treatment.
| Groups | FGFR1 mutation (n = 14) | Mutation-negative (n = 24) | |
| Cumulative rate of sperm concentration >5 million | 1 years | 14.39% | 30.00% | 0.312 | 2 years | 61.04% | 61.11% | 0.489 | Cumulative rate of sperm concentration >10 million | 1 years | 14.29% | 25.63% | 0.435 | 2 years | 38.64% | 57.58% | 0.243 | Cumulative rate of sperm concentration >15 million | 1 years | 0.00% | 21.25% | 0.075 | 2 years | 34.38% | 48.32% | 0.252 | Cumulative rate of sperm concentration >20 million | 1 years | 0.00% | 21.43% | 0.076 | 2 years | 25.93% | 35.18% | 0.455 | Ejaculate volume (mL) | 2.20 (1.40–2.26) (n = 11) | 3.06 ± 1.42 (n = 19) | 0.175 | Sperm concentration (million/mL) | 7.19 (1.00–9.91) (n = 11) | 18.80 (4.58–53.62) (n = 19) | 0.038 | Fast progressive sperm (A) (%) | 18.00 ± 19.92 (n = 11) | 16.77 ± 13.00 (n = 19) | 0.839 | Sperm progressive motility (A + B) (%) | 33.83 ± 26.31 (n = 11) | 34.88 ± 22.71 (n = 19) | 0.909 | Sperm total mobility (A + B + C) (%) | 37.26 ± 29.21 (n = 11) | 40.38 ± 24.91 (n = 19) | 0.759 |
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Sperm concentration, sperm volume, fast progressive sperm, sperm progressive motility, and sperm total mobility were obtained from the last visit.
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