Postoperative Nomogram for Predicting Cancer-Specific and Overall Survival among Patients with Medullary Thyroid Cancer

Table 2

Univariate and multivariate cox regression analysis of overall survival (OS) in the training cohort.

Characteristics	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Age (y)
<48	Reference			Reference
48–71	6.965	3.363–14.425	≤0.001	7.635	3.675–15.863	≤0.001
>71	21.564	10.108–46.003	≤0.001	22.406	10.384–48.346	≤0.001
Race
Black	Reference
White	0.764	0.421–1.388	0.377	—	—	—
Others	0.574	0.215–1.531	0.268	—	—	—
Sex
Male	Reference
Female	0.571	0.402–0.811	0.002	—	—	—
Number of nodules
Solitary	Reference
Multiple	0.620	0.410–0.939	0.024	—	—	—
Tumor size(mm)
<20	Reference			Reference
20–40	2.429	1.512–3.902	≤0.001	2.369	1.468–3.824	≤0.001
>40	5.347	3.338–8.567	≤0.001	3.178	1.948–5.186	≤0.001
T
T1a	Reference
T1b	1.362	0.597–3.106	0.463	—	—	—
T2	2.050	0.976–4.309	0.058	—	—	—
T3a	3.505	1.659–7.404	≤0.001	—	—	—
T3b	4.787	2.337–9.808	≤0.001	—	—	—
T4a	9.006	4.236–19.148	≤0.001	—	—	—
T4b	6.743	2.736–16.615	≤0.001	—	—	—
N
N0	Reference
N1a	2.452	1.500–4.007	≤0.001	—	—	—
N1b	3.017	1.966–4.628	≤0.001	—	—	—
M
M0	Reference			Reference
M1	6.117	3.984–9.392	≤0.001	3.936	2.488–6.227	≤0.001
Number of removal LNs
1–3	Reference
≥4	1.117	0.709–1.762	0.632	—	—	—
Total LNs
0–11	Reference
12–32	1.268	0.820–1.960	0.285	—	—	—
33–90	1.645	1.088–2.486	0.018	—	—	—
pLNs
0	Reference
1–16	2.357	1.551–3.584	≤0.001	—	—	—
17–63	4.246	2.557–7.050	≤0.001	—	—	—
LNR
<19.00%	Reference			Reference
19.00%–49.00%	2.092	1.326–3.301	0.002	1.603	1.006–2.554	0.047
>49.00%	4.441	2.966–6.649	≤0.001	3.006	1.974–4.577	≤0.001

HR, hazard ratio; CI, confidence interval; means .