The Phlorotannin-Rich Fraction of Ecklonia cava Extract Attenuated the Expressions of the Markers Related with Inflammation and Leptin Resistance in Adipose Tissue

Figure 1

Effects of E. cava extract on body weight, adiposity, food intake, and adipocyte sizes in high-fat diet- (HFD-) induced obese mice. Mice fed with standard normal fat diet (NFD; open bar) or HFD (HFD; black bar) for 4 weeks and then 0.9% saline (NFD/saline group and HFD/saline group), 70 mg/kg/day E. cava extract (HFD/ECE group; red bar) or 500 mg/kg/day Garcinia cambogia extract (HFD/GCE group; blue bar) orally administrated for the next 4 weeks. After 8 weeks of administration, (a) body weight, (b) fat mass, (c) lean mass, and (d) food intake were measured. (e) Hematoxylin and eosin (H&E) stained images showing adipocytes in visceral fat and (f) a graph showing average visceral adipocyte size in representative H&E stained images. Adipocyte size was expressed as folds of that of NFD/saline group. Scale bar = 200 μm. The same letters represent no significant difference ().

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