Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis

Table 3

Comparison of thyroid autoantibodies and oxidative stress markers before and after treatment within each group.

Group	Pretreatment	Posttreatment
TPOAb (IU/ml)
Selenium (n = 18)	603.0 (121.0, 846.0)	497.0 (82.0, 706.0)	<0.001
Placebo (n = 14)	581.0 (91.0, 802.0)	569.0 (90.0, 814.0)	0.110
TgAb (IU/ml)
Selenium (n = 18)	482.0 (92.0, 718.0)	454.0 (89.0, 716.0)	0.081
Placebo (n = 14)	501.0 (46.0, 692.0)	486.0 (50.0, 702.0)	0.363
TSH (μIU/mL)
Selenium (n = 18)	1.69 (1.10, 3.02)	1.41 (0.58, 2.17)	0.734
Placebo (n = 14)	1.94 (0.92, 2.77)	2.12 (1.78, 3.56)	0.935
MDA (nmol/ml)
Selenium (n = 18)	6.8 ± 1.3	4.9 ± 0.7	<0.001
Placebo (n = 14)	7.0 ± 1.6	7.2 ± 1.2	0.700
TAC (mmol/l)
Selenium (n = 18)	10.0 ± 1.9	12.9 ± 3.1	0.003
Placebo (n = 14)	10.5 ± 2.5	9.2 ± 2.7	0.171
SOD (U/ml)
Selenium (n = 18)	72.3 ± 10.3	84.3 ± 13.2	0.007
Placebo (n = 14)	69.1 ± 9.1	68.3 ± 11.4	0.832

TSH: thyroid stimulating hormone; TPOAb: thyroid peroxidase antibody; TgAb: antithyroglobulin antibody; MDA: malondialdehyde; TAC: total antioxidant capacity; SOD: superoxide dismutase.