A Missense Mutation in IRS1 is Associated with the Development of Early-Onset Type 2 Diabetes

<div>Family tree of the family. The solid black box indicates the proband, box indicates males, circle indicates females, oblique line indicates death, and red indicates diabetes. The proband (<b>III-5</b>), his brother (<b>III-4</b>), his father (<b>II-3</b>), his uncle (<b>II-2</b>), and his aunt (<b>II-1</b>) were diagnosed with T2DM at the age of 32, 45, 56, 48, and 64, respectively.</div>

International Journal of Endocrinology

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Figure 1

Figure 1: A Missense Mutation in IRS1 is Associated with the Development of Early-Onset Type 2 Diabetes 