Research Article
A Missense Mutation in IRS1 is Associated with the Development of Early-Onset Type 2 Diabetes
Table 6
Evolutionary conservation analysis for the p.His713Tyr mutation in IRS1.
| Protein acc. | Gene | Organism | Amino acid sequences |
| NP_005535.1 | IRS1 | H. sapiens | 697 | KLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSP | 746 | XP_001134895.1 | IRS1 | P. troglodytes | 696 | KLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSP | 745 | XP_543274.3 | IRS1 | C. lupus | 696 | KLWTNGVGGHHPHALPHPKLPVESGSGKLLSCTGDYMNMSPVGDSNTSSP | 745 | XP_003585821.1 | IRS1 | B. taurus | 697 | KLWTNGVGGHHSHALPHPKLPVESGSGKLLSCTGDYMNMSPVGDSNTSSP | 746 | NP_034700.2 | Irs1 | M. musculus | 692 | KPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSP | 741 | NP_037101.1 | IRS1 | R. norvegicus | 692 | KPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSP | 741 | XP_004951158.1 | IRS1 | G. gallus | 767 | KIWTNGAG-----------------HHPKLSVESNEGKLPCGGGDYINMSPASGSTTSTP | 809 | XP_005157831.1 | IRS1 | D. rerio | 631 | KIWTNG------------------------INPKLSVESMEGKVSSC-GDYINMSPASCSTTSTP | 670 |
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