A Missense Mutation in IRS1 is Associated with the Development of Early-Onset Type 2 Diabetes

Table 6

Evolutionary conservation analysis for the p.His713Tyr mutation in IRS1.

Protein acc.	Gene	Organism	Amino acid sequences
NP_005535.1	IRS1	H. sapiens	697	KLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSP	746
XP_001134895.1	IRS1	P. troglodytes	696	KLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSP	745
XP_543274.3	IRS1	C. lupus	696	KLWTNGVGGHHPHALPHPKLPVESGSGKLLSCTGDYMNMSPVGDSNTSSP	745
XP_003585821.1	IRS1	B. taurus	697	KLWTNGVGGHHSHALPHPKLPVESGSGKLLSCTGDYMNMSPVGDSNTSSP	746
NP_034700.2	Irs1	M. musculus	692	KPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSP	741
NP_037101.1	IRS1	R. norvegicus	692	KPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSP	741
XP_004951158.1	IRS1	G. gallus	767	KIWTNGAG-----------------HHPKLSVESNEGKLPCGGGDYINMSPASGSTTSTP	809
XP_005157831.1	IRS1	D. rerio	631	KIWTNG------------------------INPKLSVESMEGKVSSC-GDYINMSPASCSTTSTP	670