Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism?

Figure 2

Illustration of the AR signalling pathway. When A enters into the cell, it is converted into the more potent DHT by 5α-reductase and binds to the ligand-binding pocket of AR forming AR-A and AR-DHT complexes, respectively. Consequently, the AR-A or AR-DHT is translocated into the nucleus with help of other proteins to form the AR-dimer (or AR-DHT dimer, not shown) that is able to bind the ARE region in DNA to regulate the expression of downstream genes thus initiating the transcription of specific protein that exert the androgen effect.