Is There a Nonlinear Relationship between Serum Uric Acid and Lipids in a Hypertensive Population with eGFR ≥30 ml/min/1.73 m2? Findings from the China Hypertension Registry Study
Table 2
Association between SUA and lipids.
Variables
Crude model
Model 1
Model 2
βa (95% CI)
value
βa (95% CI)
value
βa (95% CI)
value
TG (mmol/L)
SUA (per 1 mg/dL change)
0.11 (0.10, 0.12)
<0.001
0.16 (0.15, 0.18)
<0.001
0.15 (0.14, 0.16)
<0.001
Tertiles
T1 (<5.57)
Reference
Reference
Reference
T2 (5.57–8.39)
0.18 (0.13, 0.23)
<0.001
0.31 (0.26, 0.36)
<0.001
0.26 (0.21, 0.31)
<0.001
T3 (≥8.39)
0.42 (0.37, 0.47)
<0.001
0.63 (0.58, 0.68)
<0.001
0.54 (0.48, 0.60)
<0.001
for trend
<0.001
<0.001
<0.001
LDL-C (mmol/L)
SUA (per 1 mg/dL change)
0.03 (0.02, 0.04)
<0.001
0.06 (0.06, 0.07)
<0.001
0.06 (0.05, 0.07)
<0.001
Tertiles
T1 (<5.57)
Reference
Reference
Reference
T2 (5.57–8.39)
0.06 (0.03, 0.10)
<0.001
0.15 (0.12, 0.18)
<0.001
0.13 (0.10, 0.16)
<0.001
T3 (≥8.39)
0.10 (0.07, 0.14)
<0.001
0.25 (0.21, 0.28)
<0.001
0.22 (0.18, 0.25)
<0.001
for trend
<0.001
<0.001
<0.001
HDL-C (mmol/L)
SUA (per 1 mg/dL change)
−0.02 (−0.03, −0.02)
<0.001
−0.02 (−0.02, −0.01)
<0.001
−0.01 (−0.01, 0.01)
0.083
Tertiles
T1 (<5.57)
Reference
Reference
Reference
T2 (5.57–8.39)
−0.05 (−0.07, −0.04)
<0.001
−0.05 (−0.06, −0.03)
<0.001
−0.02 (−0.04, −0.01)
0.021
T3 (≥8.39)
−0.09 (−0.11, −0.07)
<0.001
−0.07 (−0.09, −0.05)
<0.001
−0.02 (−0.04, 0.01)
0.107
for trend
<0.001
<0.001
0.104
Abbreviations: CI, confidence interval; SUA, serum uric acid; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol. Crude model: unadjusted; model 1: adjusted for age, sex; model 2: adjusted for age, sex, smoking, alcohol use, stroke, diabetes, antihypertensive drugs, lipid-lowering drugs, glucose-lowering drugs, BMI, SBP, DBP, Hcy, FBG and eGFR. aIndicated effect sizes (β) were combined by Rubin’s rule.
