Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8

Figure 1

Resistin inhibits the production of glycogen. Eight-week-old male C57BL/6J mice were treated with or without resistin, and the PAS staining (a) and the glycogen content (b) measured by the glycogen assay kit (Nanjing Jiancheng Bioengineering Institute, China) were used to assess the glycogen content directly. HepG2 cells were treated with human recombinant resistin protein, and the glycogen content in cells (c) and glucose levels in the medium (d) measured. Eight-week-old male C57BL/6J mice (e) or HepG2 cells (f) were treated with or without resistin and the genes related to glycogen metabolism (GS, GSK3β, and GP) were analyzed by using qRT-PCR. Data are presented as mean ± SD. and .

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