Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8

<div>p65 binds directly to the K8 promoter. (a) The luciferase activity of the plasmid containing the pGL3-K8 promoter was greatly increased compared with that of control. (b) Schematic of the putative K8 promoter with two potential p65 response elements. (c) Luciferase assays in HEK293A cells. p65 significantly increased the luciferase activity of the vector containing the pGL3-K8 promoter. (d) Chromatin immunoprecipitation assays revealed that p65 interacts with the K8 promoter. 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International Journal of Endocrinology

fig3

Figure 3

Figure 3: Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8 