Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes
Table 1
Difference of baseline characteristics of subjects according to the use of metformin.
Variable
Metformin user
Metformin nonuser
P
n
706 (82.3%)
152 (17.7%)
Sex, male/female
0.210
Male, n (%)
321 (80.5%)
78 (19.5%)
Female, n (%)
385 (83.9%)
74 (16.1%)
Age, years old
59.42 ± 9.77
63.16 ± 9.87
<0.001
Duration of diabetes, years
12.61 ± 7.23
14.16 ± 8.12
0.020
Body weight, kg
66.75 ± 11.68
64.39 ± 11.16
0.023
Body mass index, kg/m2
25.44 ± 3.46
24.67 ± 3.23
0.013
Waist circumference, cm
89.02 ± 8.73
86.56 ± 7.93
0.004
Chest circumference, cm
94.49 ± 7.27
92.69 ± 7.43
0.042
Hip circumference, cm
95.2 ± 6.55
93.21 ± 6.44
0.002
Glycosylated hemoglobin, %
7.45 ± 1.27
7.1 ± 1.37
0.002
Fasting plasma glucose, mg/dL
150 ± 49.62
140.88 ± 56.09
0.063
Urine microalbumin, μg/mg Cr
39.04 ± 110.86
50.46 ± 141.85
0.371
Serum creatinine, mg/dL
0.82 ± 0.28
1.11 ± 1.35
0.010
Creatinine clearance, ml/min
96.52 ± 28.8
84.5 ± 30.98
<0.001
ALT, IU/L
23.24 ± 23.00
24.29 ± 15.63
0.011
Total cholesterol, mg/dL
161.71 ± 32.86
173.29 ± 36.64
<0.001
Triglyceride, mg/dL
146.92 ± 87.65
133.75 ± 73.27
0.056
LDL cholesterol, mg/dL
89.73 ± 28.84
100.5 ± 31.22
<0.001
HDL cholesterol, mg/dL
48.44 ± 13.07
51.51 ± 15.65
0.027
ALT, alanine transaminase; LDL, low-density lipoprotein; and HDL, high-density lipoprotein. Results are expressed as mean ± standard deviation or n (%). P value for the t-test comparing the both groups with and without metformin.
