Recurrent Germline Mutations of CHEK2 as a New Susceptibility Gene in Patients with Pheochromocytomas and Paragangliomas

Figure 4

Immunohistochemical staining of the phosphorylated p53 Ser20. (a) Staining for normal gland (positive control: the nucleus was positive for p53 Ser20), (b) for Patient 1 (negative for p53 Ser20), (c) for Patient 2 (the nucleus was negative but partial cytoplasm was positive for p53 Ser20), (d) for Patient 3 (negative for p53 Ser20), and (e) for Patient 4 (the nucleus was negative but partial cytoplasm was weak positive for p53 Ser20).

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