PIK3R1, SPNB2, and CRYAB as Potential Biomarkers for Patients with Diabetes and Developing Acute Myocardial Infarction

Figure 6

Validation of screened hub genes in human blood samples. (a) The protein expression levels of human blood samples between diabetes patients with and without AMI utilizing ELISA analysis, including PIK3R1, SPNB2, and CRYAB. (b) There is no significant difference in the hospital stay between diabetes patients with and without AMI. (c) The AUCs of three screened proteins of human blood samples between diabetes patients with and without AMI, including PIK3R1, SPNB2, and CRYAB, suggesting the three hub genes can be the diagnostic biomarkers for diabetic patients undergoing AMI. The protein expression levels of diabetic AMI patients’ blood samples between before and after treatment utilizing ELISA analysis, including PIK3R1 (d), SPNB2 (e), and CRYAB (f). (g–h) There is no significant difference in the hospital stays between the diabetic AMI patients with high PIK3R1 and SPNB2 expression level and with low PIK3R1 and SPNB2 expression level. (i) The diabetic AMI patients with low PIK3R1 and SPNB2 expression level had the longer hospital stays compared to those with high PIK3R1 and SPNB2 expression level. (j) The AUCs of three screened proteins of diabetic AMI patients’ blood samples before and after treatment, including PIK3R1, SPNB2, and CRYAB, suggesting the three hub genes can be the prognostic biomarkers for patients with diabetes and undergoing AMI. ; ns, not significant.

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