International Journal of Endocrinology

Review Article

Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men

Table 1

Pathologies and circulating levels of SHBG.


	Author	Condition	Sex	Age (years)	SHBG (nmol/l)	value	Change

Obesity	Kopelman et al. [121]	Lean control	Women	28	60 ± 8
	Kopelman et al. [121]	Obese	Women	29	30 ± 4	Non reported	Decreased
	Cupisti et al. [122]	BMI < 25 kg/m²	Women	26.41 ± 6.09	53.42 ± 23.1
	Cupisti et al. [122]	BMI > 25 kg/m²	Women	29.23 ± 7.08	30.03 ± 14.52	<0.0001	Decreased
	Nokoff et al. [116]	Normal weight	Women	10	59.5
		Obese	Women	10	18.5	<0.0001	Decreased
		Normal weight	Men	12	57
		Obese	Men	12	18	<0.0001	Decreased

Diabetes	Lindstedt et al. [123]	Control	Women	38–60	88 ± 55
	Lindstedt et al. [123]	Diabetes	Women	38–60	55 ± 31	<0.001	Decreased
	Laaksonen et al. [25]	Control	Men	51.3 ± 6.7	34.5
		Metabolic syndrome	Men	51.4 ± 6.8	28.2	<0.001	Decreased
		Diabetes	Men	52.2 ± 5.6	26.2	<0.001	Decreased
	Ding et al. [110]	Normal	Women	60.3 ± 6.1	36.9 ± 17.4
		Type 2 diabetes	Women	60.3 ± 6.1	22.3 ± 13.8	<0.001	Decreased
		Normal	Men	63.7 ± 7.6	27.3 ± 10.7
		Type 2 diabetes	Men	63.7 ± 7.6	19.6 ± 7.2	<0.001	Decreased

PCOS	Ferk et al. [124]	Control	Women	25.3 ± 3.8	61.0 ± 14.7
	Ferk et al. [124]	PCOS	Women	24.4 ± 4.4	44.4 ± 19.1	<0.001	Decreased
	Baldani et al. [125]	Control	Women	31.3 ± 4.8	71.6 ± 21.7
	Baldani et al. [125]	PCOS	Women	28.3 ± 5.7	38.4 ± 19.9	<0.001	Decreased

Hypothyroidism	Leger et al. [126]	Euthyroid	Boys and girls	7.1 ± 0.5	77.8 ± 7.9
Hypothyroidism	Leger et al. [126]	Hypothyroid	Boys and girls	7.1 ± 0.5	48.2 ± 6.5	<0.01	Decreased

Klinefelter syndrome	Plymate et al. [127]	Normal	Men	24–40	6.5 ± 1.2
	Plymate et al. [127]	XXY Klinefelter’s	Men	20–45	16.4 ± 2	Not reported	Increased
	Estour et al. [128]	Normal weight	Women		25.6 ± 62.9
	Estour et al. [128]	Anorexia	Women	20 (14–35)	90.8 ± 32.6	<0.001	Increased

Malnutrition	Pascal et al. [129]	Control	Boys and girls	16 ± 8 months	0.11 ± 0.03
Malnutrition	Pascal et al. [129]	Kwashiorkor patients	Boys and girls	20 ± 8 months	0.18 ± 0.07 μmol/l	<0.0005	Increased

The table shows different diseases and some studies that describe the associated circulating SHBG levels. Gender, mean age (±standard deviation), and p value change between different conditions are also presented.