International Journal of Endocrinology / 2021 / Article / Tab 1 / Review Article
Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men Table 1 Pathologies and circulating levels of SHBG.
Author Condition Sex Age (years) SHBG (nmol/l) valueChange Obesity Kopelman et al. [121 ] Lean control Women 28 60 ± 8 Obese Women 29 30 ± 4 Non reported Decreased Cupisti et al. [122 ] BMI < 25 kg/m2 Women 26.41 ± 6.09 53.42 ± 23.1 BMI > 25 kg/m2 Women 29.23 ± 7.08 30.03 ± 14.52 <0.0001 Decreased Nokoff et al. [116 ] Normal weight Women 10 59.5 Obese Women 10 18.5 <0.0001 Decreased Normal weight Men 12 57 Obese Men 12 18 <0.0001 Decreased Diabetes Lindstedt et al. [123 ] Control Women 38–60 88 ± 55 Diabetes Women 38–60 55 ± 31 <0.001 Decreased Laaksonen et al. [25 ] Control Men 51.3 ± 6.7 34.5 Metabolic syndrome Men 51.4 ± 6.8 28.2 <0.001 Decreased Diabetes Men 52.2 ± 5.6 26.2 <0.001 Decreased Ding et al. [110 ] Normal Women 60.3 ± 6.1 36.9 ± 17.4 Type 2 diabetes Women 60.3 ± 6.1 22.3 ± 13.8 <0.001 Decreased Normal Men 63.7 ± 7.6 27.3 ± 10.7 Type 2 diabetes Men 63.7 ± 7.6 19.6 ± 7.2 <0.001 Decreased PCOS Ferk et al. [124 ] Control Women 25.3 ± 3.8 61.0 ± 14.7 PCOS Women 24.4 ± 4.4 44.4 ± 19.1 <0.001 Decreased Baldani et al. [125 ] Control Women 31.3 ± 4.8 71.6 ± 21.7 PCOS Women 28.3 ± 5.7 38.4 ± 19.9 <0.001 Decreased Hypothyroidism Leger et al. [126 ] Euthyroid Boys and girls 7.1 ± 0.5 77.8 ± 7.9 Hypothyroid Boys and girls 7.1 ± 0.5 48.2 ± 6.5 <0.01 Decreased Klinefelter syndrome Plymate et al. [127 ] Normal Men 24–40 6.5 ± 1.2 XXY Klinefelter’s Men 20–45 16.4 ± 2 Not reported Increased Estour et al. [128 ] Normal weight Women 25.6 ± 62.9 Anorexia Women 20 (14–35) 90.8 ± 32.6 <0.001 Increased Malnutrition Pascal et al. [129 ] Control Boys and girls 16 ± 8 months 0.11 ± 0.03 Kwashiorkor patients Boys and girls 20 ± 8 months 0.18 ± 0.07 μ mol/l <0.0005 Increased
The table shows different diseases and some studies that describe the associated circulating SHBG levels. Gender, mean age (±standard deviation), and p value change between different conditions are also presented.