Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study
Table 1
Demographic and clinical characteristics of study population.
Variables
Non-MCI (n = 172)
MCI (n = 75)
Z or
value
Age (year)
56.5 (53–64)
62 (56–67)
−3.081
0.002
Male (n (%))
93 (54.1%)
36 (48%)
0.771
0.380
Education (years)
12 (9–12)
9 (9–12)
−3.333
0.001
BMI
25.8 (24.6–26.7)
26.4 (25.6–27.3)
−2.423
0.015
Diabetes duration (years)
8.13 (7.55–8.72)
8.97 (8.28–9.74)
−5.971
<0.001
Smoking
48 (27.9%)
27 (36%)
1.618
0.203
Drinking
38 (22.1%)
22 (29.3%)
1.489
0.222
Hypertension
68 (39.5%)
35 (46.7%)
1.093
0.296
FBG (mmol/L)
8.91 (8.64–9.15)
8.9 (8.67–9.16)
−0.389
0.697
HbA1c (%)
9.45 (9.19–9.63)
9.59 (9.4–9.75)
−3.551
<0.001
TG (mmol/L)
2.55 (2.21–2.85)
2.71 (2.42–2.98)
−2.560
0.010
TC (mmol/L)
6.04 (5.78–6.35)
6.24 (5.88–6.49)
−2.199
0.028
LDL-C (mmol/L)
3.53 (3.26–3.78)
3.76 (3.32–3.97)
−2.699
0.007
HDL-C (mmol/L)
1.74 (1.54–2.03)
1.67 (1.46–1.82)
−2.458
0.014
Creatinine (μmol/L)
79.1 (71.3–84.1)
80.2 (76–84.3)
−1.560
0.119
Hs-CRP (ng/mL)
2.1 (1.77–2.42)
2.45 (2.15–2.64)
−5.346
<0.001
FT3 (pmol/L)
4.24 (3.91–4.66)
3.97 (3.71–4.30)
−2.577
<0.001
FT4 (pmol/L)
13.7 (12.9–14.9)
13.4 (12.2–14.4)
−2.309
0.017
TSH (mIU/L)
2.73 (2.33–3.14)
2.96 (2.60–3.26)
−3.193
0.001
MoCA
28 (27–29)
23 (22–24)
−12.597
<0.001
Abbreviations: T2DM: type 2 diabetes; BMI: body mass index; FBG: fasting blood glucose; HbAlc: glycosylated hemoglobin; TG: triglyceride; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; hs-CRP: high sensitivity C-reactive protein; MoCA: Montreal Cognitive Assessment. Data are expressed as medians and interquartile ranges (IQR) for quantitative variables and expressed as cases and percentages for category variables. Mann–Whitney U test (Z), or test was used to test for significant differences. FT3: serum-free triiodothyronine; FT4:serum-free thyroxine; TSH: thyroid stimulating hormone.
