Research Article
Minor Change of Plasma Renin Activity during the Saline Infusion Test Provide an Auxiliary Diagnostic Value for Primary Aldosteronism
Table 2
Diagnostic values for combined criteria using various combinations of SIT parameters.
| | Criteria | A | B | C | D | E |
| | Post-SIT PRA < 0.36 (ng/ml/h) | √ | | | | | | ΔPRA ≤ 0.5 (ng/ml/h) | | √ | | | √ | | Post-SIT ARR > 34 (ng/dl)/(ng/ml/h) | | | √ | | √ | | Post-SIT PAC/ΔPRA > 21 (ng/dl)/(ng/ml/h) | | | | √ | | | Predictive measures: Est. % (95% CI) | | | | | | | Sensitivity | 85.4% | 90.3% | 89.2% | 90.6% | 81.6% | | (79.5–90.2) | (85.1–94.1) | (83.8–93.3) | (85.3–94.6) | (75.3–86.9) | | Specificity | 74.8% | 75.6% | 90.7% | 84.3% | 97.0% | | (70.2–79.1) | (71.0–79.8) | (87.3–93.4) | (80.3–87.8) | (94.6–98.4) | | PPV | 62% | 64.0% | 82.1% | 72.1% | 92.6% | | (55.7–67.9) | (57.8–69.8) | (76.1–87.1) | (65.6–78.0) | (88.5–94.1) | | NPV | 91.4% | 94.2% | 94.6% | 95.3% | 91.6% | | (87.8–94.3) | (90.9–96.5) | (91.8–96.7) | (92.4–97.3) | (88.5–94.1) | | +L | 3.90 | 3.70 | 9.54 | 5.79 | 26.19 | | −L | 0.20 | 0.13 | 0.12 | 0.11 | 0.15 | | Youden | 0.602 | 0.659 | 0.798 | 0.749 | 0.785 | | AUC | 0.855 | 0.897 | 0.973 | 0.893 | 0.951 | | (0.823–0.882) | (0.869–0.920) | (0.960–0.982) | (0.864–0.917) | (0.930–0.967) |
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Post-SIT ARR, aldosterone-to-renin ratio after the saline infusion test; Post-SIT PRA, plasma renin activity after the saline infusion test; PPV, positive-predictive value; NPV, negative-predictive value; AUC, area under the curve; +L, positive likelihood ratio; −L, negative likelihood ratio. ΔPRA = PRA pre-SIT−PRA post-SIT; PAC post-SIT/ΔPRA = PAC post-SIT/(PRA pre-SIT−PRA post-SIT).
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