Evaluation of Thyroid Function in Patients Hospitalized for Acute Heart Failure
Table 2
Linear association of thyroid status (TSH and FT4) with cardiovascular function during hospitalization.
TSH (μIU/mL)
FT4 (ng/dL)
β (95% CI)
value
β (95% CI)
value
Heart rate, bpm
Unadjusted
−1.04 (−4.38 to 2.30)
0.539
9.44 (−4.29 to 23.18)
0.177
Model 1a
−1.25 (−4.61 to 2.11)
0.465
9.16 (−4.71 to 23.03)
0.194
Blood pressure
Systolic BP, mmHg
Unadjusted
2.15 (−1.71 to 6.01)
0.274
−9.97 (−25.42 to 5.48)
0.205
Model 1a
1.88 (−1.95 to 5.72)
0.334
−8.51 (−24.03 to 7.01)
0.281
Diastolic BP, mmHg
Unadjusted
2.74 (0.34 to 5.13)
0.025
−3.24 (−13.13 to 6.66)
0.519
Model 1a
2.68 (0.27 to 5.09)
0.030
−3.01 (−13.01 to 7.00)
0.554
BNP, pg/mL
Unadjusted model
0.02 (−0.12 to 0.15)
0.828
0.28 (−0.26 to 0.82)
0.305
Model 1a
0.05 (−0.08 to 0.19)
0.439
0.19 (−0.34 to 0.72)
0.478
Echocardiographic measures
LV ejection fraction, %
Unadjusted model
−2.16 (−7.30 to 2.98)
0.401
−29.05 (−52.24 to −5.85)
0.016
Model 1a
−1.13 (−6.08 to 3.83)
0.649
−24.85 (−47.87 to −1.82)
0.035
PASP, mmHg
Unadjusted model
−0.45 (−4.59 to 3.70)
0.830
12.77 (−4.74 to 30.28)
0.150
Model 1a
−0.56 (−4.81 to 3.70)
0.795
13.27 (−4.45 to 31.00)
0.140
The values shown are linear regression coefficients (β) and 95% confidence intervals, estimated by uni- and multivariate linear regressions, with TSH or FT4 as the independent variable and heart rate, systolic BP, diastolic BP, BNP, LV ejection fraction, and PASP as dependent variables. TSH and BNP were log-transformed. TSH: thyroid-stimulating hormone; FT4: free thyroxine; CI: confidence interval; BP: blood pressure; BNP: B-type natriuretic peptide; LV: left ventricle; PASP: pulmonary arterial systolic pressure. aAdjusted for age and sex.
