Research Article

Incidence and Factors Associated with Postoperative Delayed Hyponatremia after Transsphenoidal Pituitary Surgery: A Meta-Analysis and Systematic Review

Table 2

The summary of outcomes.

First author (year)No of patientCriteria of delayed hyponatremiaDelayed hyponatremia, N (%)Symptomatic delayed hyponatremia, N (%)As cause for unplanned readmission within 30 days

Rajaratnam (2020)222Serum sodium <135 mmol/L on or after POD 358 (26%)11 (5%)N/A
Schur (2020)84Serum sodium <135 mmol/L, on or after POD 55 (6%)N/AN/A
Patel (2019)367Serum sodium <135 mmol/L with associated symptoms55 (15%)55 (15%)20/33
Younus (2019)584Serum sodium <135 mmol/L under routine screening on POD 6, with associated symptoms16 (2.7%)16 (2.7%)16/27
Yoon (2019)234Serum sodium <135 mmol/L on or after POD 353 (22.6%)5 (2.1%)N/A
Tomita (2019)107Serum sodium <135 mmol/L on or after POD 325 (23.4%)N/AN/A
Agam (2018)1153Serum sodium <135 mmol/L with associated symptoms48 (4.2%)48 (4.2%)N/A
Bohl (2018)172Serum sodium <135 mmol/L under screening29 (15%)11 (6%)N/A
Burke (2018)788Serum sodium <135 mmol/L with associated symptoms20 (2.5%)20 (2.5%)N/A
Deaver (2018)287Serum sodium <135 mmol/L with associated symptoms13 (4.5%)13 (4.5%)13/25
Hollon (2018)400Serum sodium <135 mmol/L on or after POD 354 (14.3%)N/AN/A
Krogh (2018)314Serum sodium <130 mmol/L on POD 6–826 (8.3%)14 (4.46%)14/56
Bohl (2016)303Serum sodium <135 mmol/L with associated symptoms15 (4.95%)15 (4.95%)15/27
Barber (2014)344Serum sodium <135 mmol/L on or after POD 335 (10.2%)N/AN/A
Yamada (2014)90Serum sodium <135 mmol/L on or after POD 39 (10%)N/AN/A
Hussain (2013)339Serum sodium <130 mmol/L on POD 6–1350 (15%)22 (6.4%)N/A
Mamelak (2013)300Serum sodium <133 mmol/L on or after POD 337 (12.33%)8 (2.67%)8/38
Chen (2011)385Serum sodium <135 mmol/L on or after POD 385 (22.1%)N/AN/A
Kinoshita (2011)88Serum sodium <135 mmol/L with associated symptoms27 (30.7%)9 (10.2%)N/A
Zada (2010)169Serum sodium <135 mmol/L on or after POD 34 (2%)N/AN/A
Lee (2008)94Serum sodium <135 mmol/L on or after POD 317 (18%)7 (7.4%)N/A
Zada (2007)369Serum sodium <135 mmol/L on or after POD 3103 (28%)29 (7.9%)N/A
Sata (2006)105Serum sodium <135 mmol/L on or after POD 324 (22%)4 (3.64%)N/A
Hensen (1999)1571Serum sodium <132 mmol/L on or after POD 337 (2.4%)32 (2.1%)N/A
Kelly (1995)99Serum sodium <135 mmol/L on or after POD 39 (9%)7 (7%)N/A
Taylor (1995)2297Serum sodium <135 mmol/L with associated symptoms53 (2.3%)53 (2.3%)N/A
Sane (1994)91Serum sodium <132 mmol/L on or after POD 332 (35%)18 (19.8%)N/A

POD, postoperative day; N/A, not applicable.