Incidence and Factors Associated with Postoperative Delayed Hyponatremia after Transsphenoidal Pituitary Surgery: A Meta-Analysis and Systematic Review

Table 3

Stratified meta-analysis of the incidence of delayed hyponatremia.

	Number of studies	Q statistics	I-square (%)	Pooled event rate with 95% CI
Type of surgery
eTSS	11	164.8	93.9	0.113 (0.075, 0.168)
mTSS	7	280.2	97.7	0.092 (0.036, 0.218)
Publication year
Before 2011	10	471.3	98.1	0.121 (0.056, 0.241)
2011+	17	269.6	94.1	0.097 (0.068, 0.135)
Mean age
<50 years	15	433.9	96.8	0.117 (0.071, 0.185)
50+ years	10	91.2	90.1	0.121 (0.085, 0.168)
Criteria of delayed hyponatremia
Sodium <135 mmol/L	22	590.4	96.4	0.104 (0.070, 0.151)
Others	5	147.3	97.3	0.110 (0.045, 0.244)

eTSS, endoscopic transsphenoidal surgery; mTSS, microscopic transsphenoidal surgery.