Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research
Table 1
Clinical characteristics of study participants by sex.
Characteristics
All (n = 193)
Male (n = 90)
Female (n = 103)
value
Age (years)
42.6 ± 1.2
41.1 ± 1.6
44.0 ± 1.7
0.197
Smoking (n, %)
29 (15.0%)
28 (31.1%)
1 (1.0%)
<0.001
Iodine status
Iodized salt intake (n, %)
173 (89.6%)
82 (91.1%)
91 (88.3%)
0.530
UIC (μg/L)
152 (100–234)
163 (111–255)
142 (89–228)
0.085
Obesity indexes
BMI (kg/m2)
23.8 ± 3.1
24.1 ± 3.1
23.5 ± 3.1
0.231
WC (cm)
80.8 ± 9.7
83.9 ± 9.6
78.1 ± 9.0
<0.001
WHtR
0.499 ± 0.061
0.499 ± 0.059
0.498 ± 0.063
0.917
Glucolipid metabolism
TG (mmol/L)
1.07 (0.80–1.61)
1.17 (0.82–2.10)
1.01 (0.74–1.36)
0.026
TC (mmol/L)
5.01 (4.29–5.79)
4.95 (4.16–5.75)
5.13 (4.36–5.86)
0.326
LDL-C (mmol/L)
2.48 (2.04–2.98)
2.55 (2.05–2.94)
2.44 (2.02–3.01)
0.673
HDL-C (mmol/L)
1.30 (1.11–1.58)
1.19 (1.05–1.45)
1.37 (1.17–1.69)
0.001
Glucose (mmol/L)
5.20 (4.84–5.58)
5.19 (4.74–5.54)
5.22(4.91–5.59)
0.413
HbA1c (%)
5.7 (5.4–6.1)
5.7 (5.3–6.0)
5.8 (5.4–6.3)
0.476
Thyroid related hormones
TSH (mIU/L)
5.01 (4.60–6.11)
4.84 (4.55–5.58)
5.30 (4.63–6.28)
0.044
fT4 (pmol/L)
16.9 ± 0.2
17.5 ± 0.3
16.4 ± 0.2
0.002
Thyroid homeostasis
SPINA-GT (pmol/s)
1.95 ± 0.02
2.04 ± 0.03
1.88 ± 0.03
0.001
TSHI
3.98 ± 0.03
4.02 ± 0.04
3.94 ± 0.03
0.103
TTSI (mIU/L)
394 (351–465)
397 (353–462)
389 (349–469)
0.979
values of males and females. Data are shown as mean (SD), median (interquartile range), or percentage. BMI: body mass index; WC: waist circumference; WHtR: waist-height ratio; SPINA-GT: secretory capacity of the thyroid gland; TSHI: Jostel’s TSH index; TTSI: thyrotroph thyroid hormone resistance index; UIC: urinary iodine concentration; TG: triglyceride; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; HbA1c: hemoglobin A1c.
