The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring
Table 6
P values of tests for population stratification, total association, and within-family association in SOST haplotypes using QTDT.
CACTGGAT
CACTAGTC
CACCATTC
CAGTGGAT
TGGTGGAT
TAGTGGAT
Tests of population stratification
BMI
0.1345
0.7036
0.6155
0.5591
0.8234
0.9163
Arms FM
0.0785
0.3957
0.2127
0.0892
0.5264
0.0933
Trunk FM
0.0568
0.3232
0.2205
0.0973
0.3628
0.0644
Legs FM
0.2020
0.8096
0.0718
0.0677
0.0967
0.4443
Total FM
0.0434
0.5896
0.1747
0.5626
0.0895
1.0000
PFM
0.4952
0.7563
0.3280
0.4137
0.9272
0.2319
Arms LM
0.0987
0.1793
0.4772
0.3501
0.3760
0.1518
Trunk LM
0.0303
0.0728
0.4102
0.6748
1.0000
0.1411
Legs LM
0.1733
0.4275
0.4275
0.2240
0.5944
0.2561
Total LM
0.0730
0.0845
0.1240
4e-005
1.0000
0.0531
PLM
0.0365
0.8282
0.4909
0.5839
0.7417
0.6347
Tests of total association
BMI
0.3953
0.6183
0.3097
0.9612
0.3564
0.0512
Arms FM
0.0105
0.3659
0.9312
0.9970
0.7207
0.0906
Trunk FM
0.0048
0.1507
0.8193
1.0000
0.8968
0.1262
Legs FM
0.0072
0.6696
0.9652
0.7794
0.9623
0.4744
Total FM
0.0164
1.0000
0.7718
0.7693
1.0000
0.1930
PFM
0.1041
0.7912
0.6941
0.7276
0.8148
0.9042
Arms LM
0.2736
0.3777
0.5566
0.7820
0.8393
0.7380
Trunk LM
1.0000
1.0000
1.0000
0.9348
1.0000
1.0000
Legs LM
0.2736
0.5674
0.6738
0.7456
1.0000
0.9580
Total LM
0.0299
0.2871
0.3573
1.0000
0.8362
0.8887
PLM
0.4696
0.9138
0.5649
0.8140
0.8730
0.6295
Tests of within-family association
BMI
0.0857
0.9137
0.3587
0.6015
0.5560
0.3028
Arms FM
0.0087
0.2485
0.2746
0.1440
0.6497
0.0243
Trunk FM
0.0041
0.1300
0.3120
0.2244
0.3492
0.0193
Legs FM
0.0254
0.6888
0.1074
0.1533
0.1195
0.3160
Total FM
0.0105
0.3215
0.2122
0.2295
0.6707
0.0204
PFM
0.7896
0.6866
0.5433
0.3850
0.9724
0.2876
Arms LM
0.3637
0.1087
0.7530
0.3517
0.3786
0.1621
Trunk LM
1.0000
0.9068
1.0000
0.2177
1.0000
0.0386
Legs LM
0.4767
0.3316
0.6029
0.2354
0.6333
1.0000
Total LM
0.1135
0.0430
0.3482
0.0748
0.6653
0.1095
PLM
0.1585
0.8092
0.7888
0.5596
0.8334
0.8953
P 1000 permutation of within-family association
BMI
0.1220
0.9080
0.4040
0.6430
0.5910
0.3360
Arms FM
0.1110
0.4720
0.5300
0.3360
0.7690
0.1490
Trunk FM
0.0820
0.3350
0.5010
0.3850
0.5280
0.1380
Legs FM
0.0561
0.7780
0.2460
0.2990
0.2760
0.5090
Total FM
0.1610
0.4870
0.4040
0.3860
0.7330
0.1410
PFM
0.7910
0.6150
0.4260
0.2010
0.9630
0.2220
Arms LM
0.4700
0.1030
0.7530
0.5680
0.4040
0.1880
Trunk LM
0.8480
0.7370
0.7420
0.1440
0.7540
0.0850
Legs LM
0.4440
0.2780
0.5140
0.1030
0.5810
0.9570
Total LM
0.4310
0.2490
0.5320
0.1830
0.7620
0.3440
PLM
0.1130
0.7580
0.7230
0.5070
0.7970
0.8850
BMI: body mass index; QTDT: quantitative transmission disequilibrium test; FM: fat mass; LM: lean mass; PFM: percentage of FM; and PLM: percentage of LM. BMI and body composition phenotype values are adjusted for age. Bold numbers indicate significant values .
