PERK-Dependent Activation of the JAK2/STAT3 Pathway Contributes to High Glucose-Induced Extracellular Matrix Deposition in Renal Tubular Epithelial Cells
Table 1
The protein levels of TGF-β1, FN, and collagen I in different concentrations of glucose at different times.
TGF-β1 (ng/L)
FN (μg/ml)
Coll I (ng/L)
Mean ± SD
Mean ± SD
Mean ± SD
NC/12 h
1277.52 ± 126.83
—
578.46 ± 62.22
—
82.47 ± 6.83
—
Mann/12 h
1259.70 ± 154.35
1.00
575.66 ± 113.15
1.00
85.50 ± 8.81
1.00
H15/12 h
1435.74 ± 144.83
0.99
1089.94 ± 171.20
<0.05
123.99 ± 15.18
<0.05
H25/12 h
1912.33 ± 244.32
0.02
1185.45 ± 252.14
<0.05
163.42 ± 10.55
<0.05
H50/12 h
1591.20 ± 200.31
0.76
1042.22 ± 119.98
0.03
149.20 ± 8.90
<0.05
NC/24 h
1280.71 ± 174.95
—
659.93 ± 76.47
—
87.54 ± 3.37
—
Mann/24 h
1267.80 ± 141.28
1.00
593.29 ± 100.33
1.00
94.36 ± 12.63
1.00
H15/24 h
1899.81 ± 192.74
0.02
1242.78 ± 157.80†
<0.05
137.62 ± 8.23†
<0.05
H25/24 h
2002.32 ± 227.84
<0.05
1499.52 ± 178.26
<0.05
205.16 ± 9.35†
<0.05
H50/24 h
1461.57 ± 204.17
0.99
1281.24 ± 185.36
<0.05
167.17 ± 14.56
<0.05
NC/48 h
1190.83 ± 88.05
—
604.00 ± 93.41
—
89.97 ± 9.13
—
Mann/48 h
1207.14 ± 244.60
1.00
590.15 ± 75.43
1.00
81.73 ± 9.56
1.00
H15/48 h
1351.34 ± 208.61
0.99
1145.16 ± 164.25
<0.05
140.06 ± 13.63
<0.05
H25/48 h
1813.77 ± 216.90
0.02
1286.16 ± 180.00
<0.05
186.33 ± 14.73
<0.05
H50/48 h
1301.38 ± 176.79
1.00
1047.77 ± 52.37
0.04
159.40 ± 14.21
<0.05
N = 3, compared with the NC group at 12 h; compared with the NC group at 24 h, compared with the NC group at 48 h.
