Osteocalcin Alleviates Nonalcoholic Fatty Liver Disease in Mice through GPRC6A

Figure 2

The effects of osteocalcin and GPRC6ALKO on glucose tolerance and insulin sensitivity. (a), (c) Blood glucose levels in each time point and the area under curves in the intraperitoneal glucose tolerance test. (b), (d) Blood glucose levels in each time point and the area under curves in the intraperitoneal insulin tolerance test. Data were expressed as the mean ± SEM and were analyzed using independent-samples T-test. ^#, the GPRC6ALKO : HFD + NS group compared with the WT : HFD + NS group; ^&, the GPRC6ALKO : HFD + OCN group compared with the WT : HFD + OCN group. GPRC6ALKO, liver-specific conditional GPRC6A knockout; WT, wild-type; NS, saline solution; HFD, high-fat diet; OCN, osteocalcin. The effects of osteocalcin and GPRC6ALKO on HFD-induced hepatic steatosis.

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